Clinical trials play a crucial role in pharmaceutical research, providing the foundation for the development and approval of new drugs and therapeutic interventions. These trials involve human participants and are designed to investigate the safety, efficacy, and pharmacological profile of pharmaceutical products. This research paper explores the methodology and ethical considerations involved in conducting clinical trials in pharmacy. It delves into the key stages of clinical trial design, implementation, and analysis, as well as the essential ethical principles and regulations that safeguard the welfare of trial participants. Understanding the principles and methodologies behind clinical trials is essential for researchers, healthcare professionals, and regulatory authorities in ensuring the integrity and success of pharmaceutical research.