Background: This study was done to study the clinical profile of children with headache. Methodology: The present study was conducted in the Dr. D. Y. Patil medical college, hospital and research Centre, Pimpri, Pune and study was carried out over a period of 2 years from July 2020 to July 2022. A total 100 children were enrolled who had complaints of headache. Ethical committee approval was taken before the start of the study. Results: Majority of the patients were in the age group of 8-10 years (56%). In the study, 53% of the subjects were females and 47% of the subjects were males. 60% of the children had more than one episode of headache per week and 40% of the children had more than two episodes in a year. 75% of children complained of having bilateral headache and 25% had unilateral headache. In our study group, 72% of children had primary headache and 28% had secondary headache. 86% patients had duration of symptoms lasting for more than 15 minutes. Nausea, photophobia, phonophobia, and dizziness were the commonest symptoms in all headache subtypes. Children with headache were graded on quality of life with help of pedMIDAS severity grading scale, 48% children were in grade 2 followed by grade 1 (23%) and grade 3 (22%). Majority of the children had mild pedMIDAS disability (44%) followed by moderate (25% ) and little to none (24%). In the present study, 17 patients underwent neuroimaging. Out of those, seven children had normal MRI findings, just had features of sinusitis without any neuro parenchymal abnormalities, only two children were found to have had obstructive hydrocephalus and other children showed various other neuro parenchymal abnormalities. Conclusion: Headache is a common neurological disorder presenting in pediatric OPD. In this study, 72% were primary headache and 28% were secondary headache. The proportion of children with primary headache was much more than secondary headache. Early diagnosis and treatment significantly affect the outcome of headache disorders in children and can improve quality of life in day-to-day activities and scholastic performance