Aim: The aim of this study was to evaluate the clinical and radiographic success of nano silver fluoride versus calcium hydroxide in indirect pulp treatment of deep caries in second primary molars. Materials and methods: This Randomized Clinical Trial included 40 vital primary second molars with deep caries in 37 healthy and cooperative children aged from 4-7 years. The teeth were randomly divided into two groups. Group I: the pulp was indirectly capped with Nanosilver fluoride and group II: the pulp was indirectly capped with Dycal. The treatment was performed in a single visit and teeth were restored with amalgam restoration as a core. After one year follow up, teeth were finally restored with stainless steel crowns. Clinical success was evaluated regularly at 1, 3, 6, 9 and 12 months while radiographic success was evaluated regularly at 6 and 12 months.