Tuberculosis is a bacterial infection disease Mycobacterium tuberculosis which is usually transmitted through inhalation of droplets containing bacteria. Moringa oleifera is an alternative to overcome the problem of healing TB patients. M. oleifera leaf extract caused significant immunostimulatory effects on the cell-mediated and humoral immune system in Wistar albino rats. The design of this study was randomized posttest only design with a control group, which was conducted on 24 male mice. In the second week, the first group were infected with Mycobacterium tuberculosis and the second group were not infected. In the third week, the first group was divided into two groups, 6 mice were given Moringa leaf extract and 6 mice were not given. The second group was also divided into two groups, 6 mice were given Moringa leaf extract (KPE) and 6 mice were not given. At the tenth week, each group of mice was measured for IFN-γ, IL-12. Data were analyzed using Mann-Whitney U test (for IFN-γ) and independent sample t-test (for IL-12). The p-value for IFN-γ and IL-12 were less than 0.05. This study concluded that administration of moringa leaf extract acts as an immunomodulator in increasing cellular immunity (IFN-γ and IL-12).