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ISSN 2063-5346
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Central composite design enabled formulation development and characterization of carvedilol polymeric nanoparticles by nanoprecipitation technique for the improved drug solubility

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Mallika Tamminana1*, and B.V.V. Ravikumar2
» doi: 10.48047/ecb/2023.12.5.287

Abstract

Carvedilol is a poorly water-soluble anti-hypertensive BCS class-II drug used to prepare a polymeric nanoparticle by nanoprecipitation technique using selected polymers such as chitosan and HPMC K15M and poloxamer 407 as a surfactant for the improvement of drug solubility through the release of drug in a sustained manner. The initial process and formulation variables are screened out based on the selected critical quality attributes such as drug release (%), entrapment efficiency (%), particle size (nm), and zeta potential (mV). The FT-IR and DSC studies reveal that the model drug has no interactions and sharp melting points with the polymers and does not show any additional peaks. The prepared drug-loaded polymeric nanoparticles were characterized for particle size, zeta potential, entrapment efficiency, and in-vitro drug release. The drug release and stability studies indicated that the F6 formulation was more stable, with improved drug solubility and good drug entrapment efficiency along the formation of the nanosized polymeric formulation. The correlation coefficient data and Korsmeyer Pappa’s release exponent values showed the formulations followed diffusion-controlled drug release non-Fickian mechanism and Higuchi kinetics. The stability study indicates that the optimized formulation (F6) is more stable for up to 6 months without changes in drug entrapment efficiency and in vitro dissolution rate.

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