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ISSN 2063-5346
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CATALYSIS BY TRIFLIC ACID: SYNTHESIS OF THE INDOLYLQUINONES AS POTENTIAL ANTITUMOR AGENT

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Feyriel Dridi[a,b], Didier Villemin [a]*, Nathalie Bar[a], Messaoud Hachemi[b] and Remi Legay[a]

Abstract

Trifluoromethanesulfonic acid efficiently catalyzes the conjugate addition of indoles to p-benzoquinones under mild conditions affording the corresponding indolylquinones in high yields with high selectivity. In particular, the poorly reactive menadione underwent reaction with indoles under similar conditions to give 3-indolylnaphthoquinones

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