Hospital janitors are not directly responsible for patient care; however, they are at risk of exposure to incidents involving biological material through frequent handling of medical waste during their work. Although about 60 blood-borne infectious pathogens have been identified, most occupation related blood borne infections are due to hepatitis B virus (HBV), hepatitis C virus (HCV) and human immunodeficiency virus (HIV). During COVID-19 pandemic, health care workers were at the front line of the response so they were exposed to the risk of infection. A systematic search was conducted in PubMed, Embase, Cochrane Library and Web of Science databases, and grey literature was searched through Google Scholar included all scientific literature published from 2016 until 2024.