Parkinson’s disease (PD) is a neurodegenerative disease that affects the motor system and has significantly accelerated over the last few years. One of the non-motor symptoms of PD is oral cavity disorders, although they are prevalent but often neglected by the patients. Aim: This study aimed to analyze the demographic profile and compare the biofilm and antibiotic resistance of oral microorganisms of elders with Parkinson’s disease (PD) and Non-PD individuals. Materials and Methods: In this study, oral samples of 33 individuals were subjected to microbiological analysis, out of which 18 were PD and 15 were Non-PD (Control). Results: Here, six different species were identified using Matrix- Assisted Laser Desorption/Ionization- Time of Flight (MALDI-TOF) technique among which three of the isolates were found to be Staphylococcus species, followed by Pseudomonas aeruginosa, Bacillus cereus, and Panebacillus thiaminolyticus. P. thiaminolyticus was absent in the Non-PD subject group. Upon comparison, no significant difference was observed in the oral bacterial strains isolated from both study groups, but there was a slight increase in the prevalence of oral microorganisms in PD patients compared to Non-PD individuals. Further, the isolates were analyzed for biofilm formation by Congo Red Agar (CRA) and Tissue Culture Plate (TCP) methods. Conclusion: About 83.3% of the isolates from the PD group and 80% of the Non-PD group showed their ability to produce biofilm. Likewise, all the isolates obtained from the PD groups were found to be resistant to a minimum of 5 or more antibiotics, among the 12 antibiotics tested. Further research is required to study the relationship between biofilm-producing multi drug resistant oral microorganisms with PD.