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ISSN 2063-5346
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BIO-ANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF CYPERMETHRIN PESTICIDE USING GC-FID METHOD

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Konatham Teja Kumar Reddy, Dr. Karthickeyan Krishnan, Dr. Shanmugasundaram Palani , B. Raj Kumar, Anupama GV, R.S Chandan
» doi: 10.31838/ecb/2023.12.sa1.002

Abstract

Cypermethrin is a synthetic pyrethroid pesticide that is used to treat various fruits and vegetables of pests. Similar to natural pyrethroid, synthetic pyrethroid is generated from pyrethrum flowers (chrysanthemum cinerariaefolium). A very simple Gas chromatography technique was developed which helps in the estimation of Cypermethrin in human plasma. The separation of the drug was achieved on drug column of Zebron GC DB. The retention time was 18.2 mins. This method was validated according to the ICH Guidelines. The linearity was calculated and the regression coefficient was found to be 0.99. The LOD and LOQ were validated. This method was applied for bio analytical with human plasma according to the USFDA guidelines.

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