High risk neonates with respiratory distress syndrome admitted to an intensive care unit usually need respiratory support as mechanical ventilation through endotracheal tube from nose or mouth to give different pressure and concentration of oxygen .High risk neonates position is very important during mechanical ventilation so the nurse should choose the effective and comfort position as prone position for the high risk neonates. Prone position is very effective in oxygenation and ventilation of high risk neonates. Objective: This study was to highlight the effect of prone position on oxygenation level for mechanically ventilated high risk neonates. Methods: PubMed, Google scholar and Science direct were searched using the following keywords: [Prone position on oxygenation level, ARDS, Mechanical ventilator, and Risk neonates]. The authors also screened references from the relevant literature, including all the identified studies and reviews, only the most recent or complete study was included between January 1999 and February 2020. Documents in a language apart from English have been excluded as sources for interpretation was not found. Papers apart from main scientific studies had been excluded: documents unavailable as total written text, conversation, conference abstract papers and dissertations. Conclusion: Prone position improve arterial blood gases, vital signs and parameters of mechanical ventilation of high risk neonates