Depression is a prevalent global public health issue. Ayurveda, an ancient system of medicine originating from India, provides a diverse range of therapeutic interventions for the management of depression. This systematic review's goal is to evaluate the effectiveness and security of Ayurvedic therapies for the treatment of vishada (depression). Methods: The study employed a thorough exploration of electronic databases such as PubMed, Embase, and Cochrane Library, with the search conducted until September 2021. The present study incorporated randomized controlled trials (RCTs) and non-randomized studies that examined the efficacy of Ayurvedic interventions in treating depression. The effectiveness of the study was assessed using the Cochrane risk of bias assessment. The data were synthesized utilizing a narrative methodology and meta-analytical techniques when deemed appropriate. Results: The review encompassed a sum of 20 studies. The study incorporated a range of interventions, comprising of herbal remedies, Ayurvedic procedures, and yoga therapy. The research findings exhibited diverse levels of enhancement in depression-related results. The findings of studies indicated notable enhancements in depressive symptoms, whereas the remaining studies reported inconclusive or insignificant outcomes. The evidence quality was assessed as being of low to moderate quality owing to limited sample sizes, heterogeneity of interventions, and potential for bias. Conclusion: The potential of Ayurvedic interventions as an alternative or supplementary treatment for depression is worth considering. Nevertheless, additional randomized controlled trials (RCTs) that are well-structured, encompass larger sample sizes, and have extended follow-up periods are required to substantiate the effectiveness and safety of Ayurvedic treatments for depression.