To study effect of telmisartan with luteolin on cognitive dysfunction in high fat diet-STZ induced diabetic rats. Material and Methods: HFD-fed rats were then injected with STZ (30 mg/kg, i.p.) to induce diabetes and were subsequently fed a HFD for an additional nine weeks. Cognitive impairment was assessed using Morris water maze and elevated plus maze models. Other parameters such as glucose levels, body weights, GSH, as well as LOP, were estimated in brain homogenates. Results: The combination treatment groups of telmisartan with luteolin exhibited a prominent decrease in glucose levels and were able to restore body weight compared to the diabetic control group and other individually treated groups. TL-I and TL-II demonstrated remarkable significance in attenuating escape latency in the water maze and transfer latency in the elevated plus maze, respectively, compared to the diabetic control group and all individually treated groups. Telmisartan plus luteolin might be due to decrease in oxidative stress via antioxidant effect of luteolin which scavenges free radicals and restores normal levels of endogenous antioxidants as well as the effect of telmisartan to decrease the glucose toxicity induced oxidative stress and cellular damage responsible for attenuation of memory in rats. Conclusion: Based on the present investigation, it can be concluded that the combination of telmisartan with luteolin synergistically attenuated cognitive dysfunction in Type 2 diabetic rats