Introduction-Health is dynamic and multifactorial in nature. It is influenced by factors like genetics, lifestyle, environment, socio economic status and many others. In this modern ever-changing world, all of us are affected at one time or another by work related stress. Methodology- This cross sectional study was conducted for one year among Night Security Guards In Meerut City. Sample size has been scientifically estimated using G Power V 3.1 Software which yielded a minimum sample size of 450. The questionnaire consisted of demographic characteristic, which included questions concerning age, gender, education, marital status and nature of work. A significant relationship was assumed to exist if the P value was found to be <0.05. Chi-square test was used to check the association of periodontal disease and oral mucosal lesion according to sociodemographic details, occupational stress and nicotine dependence. Results- The mean age was 38.48 ranging from 20 to 60 years, the age distribution was found to be discrete. Among 450 participants, 390 (86.7%) were males and 60 (13.3%) were females. Maximum participants, i.e., 126 (28%) had completed PUC and only 22 (4.9%) of them had completed diploma course. Among 450 study participants, 393 (87.3) were married and 57 (12.7%) were unmarried. Presence or absence of tobacco habit, 192 (42.7%) were smokers, 116 (25.8%) had a habit of chewing tobacco and 31 (6.8%) participants had a habit of both. Conclusion- In the present study poor oral health status is associated withoccupational stress and nicotine dependence. As these factorshave individual as well as synergistic effect on oral health.