Aim: To assess the quality of obturation using three different rotary endodontic files using CBCT Materials and Methods: 30 extracted single rooted mandibular premolars were collected. Access cavity preparation was done and working length determined. Biomechanical preparation was done using three different rotary files. Samples were divided into 3 groups and the quality of obturation was analyzed using cone beam computed tomography. Results: Profit S3 showed better obturation quality comparatively to other two file systems. Assessment of quality of obturation was statistically done using chi square test and there was a statistical significant difference between all the groups in length of obturation, quality of the obturation and density of the obturation (p=0.01). Conclusion: Among three different rotary endodontic files profit S3 has perfect obturation quality in length, density and taper next comes the Neo Endo predominantly has acceptable quality of obturation compared to protaper Gold in density, taper and length.