Background: Every diabetic patient's life is different, and the many regulations the disease forces them to abide by leave them feeling psychologically overburdened. Additionally, a number of significant issues that have a negative impact on the familial, social, and economic status of these patients include job loss, frequent hospitalization, increased demand for medical and patient care, indirect costs associated with early death, decreased social and familial interactions, and worsening lifestyle. Objectives: To assess the quality of life in patients with Diabetes. To educate/counsel the patient care regarding diseases and their complications, life-style modifications, medicines, diet restrictions in managing disease conditions. Methodology: The prospective observational and intervention study was conducted for both hospitalized inpatients as outpatients in Department of Medicine and surgery, Rajah Muthaih Medical College Hospital, Annamalai University which is a 1350 bedded tertiary care teaching hospital. Total number of samples included for this study was 143 patients using 95% confident intervals. Results: There was significant reduction in fasting blood sugar for all the three regimen users. The changes in the Fasting Blood Sugar FBS and Post Prandial Blood Sugar PPBS in each visit are as follows. Both genders had particularly low scores in the physical health with the smallest difference between groups, it indicating the bad physical conditions affecting HRQoL of diabetic patients in a similar way. Conclusion: According to the results of this investigation, the Quality Of Life QOL score improved after treatment compared to the pre-intervention study. The prevention of problems from diabetes can be greatly aided by lifestyle changes such as weight loss, altered eating patterns, quitting smoking, drinking less alcohol, and increased physical activity.