The aim of this study was to assess the level of knowledge about the emergency drugs in order to manage medical emergencies at their dental offices. Materials and Methods: The cross sectional survey was conducted among 227 dental professionals residing in Tamil Nadu through an online portal. The questionnaire consisted of four sections that addressed the demographic data, knowledge, awareness and practice regarding knowledge, experience and views of medical emergencies to manage medical emergencies at their dental offices. Result: Among the participants, 64.7% (n=147) were general dental practitioners, 20.2% (n=46) postgraduate students, and 14.9% (n=34) specialty dental practitioners. The response rate to the questionnaire achieved was 100%. There was a statistically insignificant difference between the dental practitioners based on the level of graduation. Among all the participants 173(76.2%) reported that less than 5 cases of medical emergencies have encountered in dental office in a year. About 209(92.1%) reported Dexamethosone, Nitroglycerine, Diphenhydramine, Diazepam considered as mandatory drug and using it in day to day practice. Conclusion: Management of medical emergencies should be educated at every level of study period so that the efficient patient management is achieved. In addition to that Basic Life Support should go hand in hand for managing critical patients.