The hepatoprotective potential of cadaba farinosa leaves extract was evaluated in experimental animals. Liver diseases pose a significant health burden worldwide, and the search for effective hepatoprotective agents is ongoing. In this study, we investigated the potential of Cadaba farinosa leaves extract in protecting the liver against damage induced by various hepatotoxic agents. Treatment with Cadaba farinosa extract resulted in a significant attenuation of liver damage induced by the hepatotoxic agents. Biochemical parameters such as serum levels of liver enzymes, bilirubin, and lipid peroxidation were restored to near-normal levels in the extract-treated groups compared to the control group. Histopathological examination of liver tissues further confirmed the protective effect showing reduced hepatocellular necrosis, inflammation, and fatty infiltration. Furthermore, treatment with Cadaba farinosa extract improved liver function markers, including increased levels of antioxidant enzymes and enhanced hepatic glycogen content. The extract also exhibited significant anti-inflammatory activity, as evidenced by reduced levels of pro-inflammatory cytokines in the liver.