To assess the c-reactive proteins and homocysteine levels in chronic periodontitis. Materials & methods: A total of 30 systemically healthy subjects were divided into two groups: Group I, non-periodontitis subjects and group II, chronic generalized periodontitis subjects. Gingival index was calculated. The p – value less than 0.05 was considered significant. Results: The two groups showed plaque index with score in group I as 0.65 and in group II was 2.21. The mean CRP (mg/L) levels for both groups were 0.84 and 2.36, respectively. CRP values of the two groups were significantly different from each other, with CRP levels in the group II greater than those in the group I subjects. Conclusion: Elevated levels of serum homocysteine and serum CRP levels were seen in subjects with chronic periodontitis.