Aim: The study aims to evaluate the practice of antibiotic dispensing in community pharmacies and to assess the knowledge, attitude, and practices of community pharmacists on antimicrobial resistance and dispensing antibiotics without prescription. To assess the Antibiotics dispensing pattern in community pharmacies, non-prescription antibiotic sales and commonly reported illness for the use of antibiotics. (2) To assess the knowledge and awareness of antibiotics/AMR and dispensing antibiotics without prescription among dispensers at community pharmacies. Methodology: A cross sectional descriptive study was carried out among pharmacists in the selected community pharmacies in and around Pallavaram. Pharmacists were interviewed by the investigator using a structured and validated Knowledge, attitude and practice (KAP) questionnaire regarding antibiotic resistance and dispensing of antibiotics without prescription. Results :Among the 63 community pharmacists who took part in the study, 28 of them (44%) had “very good” knowledge regarding antibiotics use and resistance; majority of them (88.9%) showed “good” attitude and 55.6% of the participants had “good” practice towards antibiotic dispensing. The most commonly dispensed antibiotics included azithromycin, erythromycin, amoxicillin, cephalexin and metronidazole. Conclusion: The present study identified that community pharmacists had ‘average’ levels of knowledge, attitude and non-prescription dispensing practices, reflecting the fact that the majority of the pharmacists were unaware of the appropriate use of antibiotics. Intervention strategies to combat antimicrobial resistance may include: health education to the general public and to the pharmacists about the personal and societal hazards of antibiotic resistance, the factors that cause it.