In the research and development of novel techniques for cutting high-strength and hard materials without altering their physical and thermal properties, abrasive jet machining (AJM) is a rapidly developing analysis area. it is seen as a potentially successful method for drilling holes in Hastelloy C-276. The topic of the current study is discussed, AJM of Hastelloy In order to assess the performance variables, specifically the material removal rate (MRR), C-276 was investigated. The input criteria considered are nozzle diameter (ND), pressure (P), and stand-off distance (SOD). The remaining parameters like type of abrasive, abrasive floe rate, size of abrasive etc., are kept constant. The response surface methodology (RSM) with a Box–Behnken method was employed in the experimentation, that concerned fifteen machining runs. Analysis of variance (ANOVA) was performed to determine the many parameters of the machining method, and therefore the optimum method With the use of response surface graphs, a parameter combination for achieving a high material removal rate was established. The air pressure is known because the primary determinant of the material removal rate, it is commonly observed that by increase in pressure the MRR increases. The RSM optimal response of process parameters on the MRR of Hastelloy C-276 and the variation in response with ANOVA are the main topics of this study