.

ISSN 2063-5346
For urgent queries please contact : +918130348310

Application of Antisense Oligonucleotides: a review

Main Article Content

Dr Kartik Mehta, Dr G G Joag, Dr R A Langade, Dr Satyajeet Jagtap
» doi: 10.31838/ecb/2023.12.si4.272

Abstract

"Antisense oligonucleotides (ASOs)" are a promising class of therapeutic compounds that have attracted a lot of attention lately because of their capacity to target and control gene expression with specificity. This review seeks to provide an overview of the present state of research on the utilization of ASOs in medicine. In-depth discussion is given regarding the mechanism of action of ASOs, which includes their capacity to bind to particular RNA molecules and suppress gene expression. The numerous types of ASOs, such as siRNA, ASOs, and miRNA inhibitors, are also detailed along with their strengths and limitations. The review highlights the numerous medical uses for ASOs, including as the therapy of cancer, infectious infections, and genetic problems. This field's most recent innovations are addressed, and their potential effects on patient care are assessed. Delivery issues and off-target effects are just two of the difficulties associated with the use of ASOs in medicine that are thoroughly covered. ASOs represent a promising therapeutic modality with a wide range of applications in medicine. While there are still some problems to be solved, recent breakthroughs in this sector have presented promising potential for the creation of innovative and effective treatments for a number of disorders.

Article Details