Plants are very useful source of various bioactive compounds which have direct and indirect use in the treatment of various human ailments. The plant named Centella asiatica belongs to the family Apiaceae showed Antimicrobial activity against various bacteria and fungi. The plant is mainly used for the treatment of wound healing , the herb is recommended for the treatment of various skin conditions such as leprosy ,lupus, ulcers. The most common bacteria that cause wound infections are Pseudomonas aeruginosa, Staphylococcus aureus, Enterococcus faecalis, Bacillus cereus and Escherichia coli causes diarrhea. The most commonly identified fungi in wounds are Candida sp, and Aspergillus sp.They cause infection usually in immunocompromised individuals. An experiment was carried out to study the antimicrobial activity of water ,ethanol, chloroform, extracts of Centella asiatica by agar well diffusion method and the phytochemical analysis was also performed for the plant extracts to detectthe presence of Alkaloids , Terpenoids , Saponin , Flavonoid. The result confirmed that the chloroform extract of Centella asiatica have higher antibacterial activity against Escherichia coli , Staphylococcus sp, Bacillus sp, Pseudomonas sp ( Ranges 10-25mm).The antifungal activity of the chloroform extract Centella asiatica showed higher range (11-17mm) of activity against Aspergillus sp. and Candida sp. Centella asiatica (Gotukola ) has been used to treat many conditions for thousand of years in India, china ,and Indonesia .It was used to heal wounds improve mental clarity and treat skin conditions .It can be consumed as a green leafy vegetable. Centella asiatica can be used in moisturizing cosmetic formulations and also to complement the treatment of dry and sensitive skin. Persons can take it by consuming the herb in capsules or as tea. The future scope of the study is to move on to the field of cosmetic microbiology, were the extracts can be used as skin care products against bacterial and fungal attacks in humans