This research aims to determine the effect of salak skin against UV exposure due to oxidative stress and hyperpigmentation. Salak skin contains antioxidants that can neutralize free radicals, prevent inflammation, and have anti-tyrosinase effects so that it can brighten the skin. This study used a posttest-only control group design using 24 white rats divided into four groups of treatments. There was positive control, and others were treated by salak skin extract in various concentration as 210 mg/kg BW, 420 mg/kg BW, and 840 mg/kg BW respectively. Histopathological staining was using MassonFontana. Melanin was added based on five fields of view per-sample. The results of the study were discussed altogether with descriptive analytics, normality, homogeneity, and ANOVA tests. We obtained that the data were normally distributed. The average amount of melanin was highest in K1 and the lowest was in K3 (p <0.05). This research suggested that salak skin extract is effective in reducing pigmentation in animals model.