Drug use evaluation (DUE) is a system of, ongoing, systematic, criteria-based drug evaluation that ensures the appropriate use of drugs. DUE data can be collected at national or regional level from the sources derived from quantitative or qualitative data, which makes it either prospective, concurrent or retrospective. The steps of a DUE are: Step 1: Establish responsibility,Step 2: Develop the scope of activities and define the objectives: Step 3: Establish criteria for review of the medicine,Step 4: Data collection,Step 5: Data analysis, Step 6: Feedback to the prescribers and planning of action and Step 7: Follow-up Methodology: A Prospective drug utilization review study was conducted at inpatient department of Basaweshwar teaching hospital and general Hospital, Sedam Road, Kalaburagi. During the course of 08 months study from 10/7/2021 12/03/2022, all the epileptic and non-epileptic patients who were prescribed with AEDs except patients below the age of 18 years were enrolled in study. Data were collected from the prescriptions, case sheets, laboratory data, scan reports and diagnosis reports for information about demographic and use of AEDs.