The review show the role of Nonsteroidalanti inflammatory agents and their moieties in key biological processes. They are wide used group of medicines derivatives utilized to treat a variety of medical pain conditions. One of these classes of drugs is naproxen that is commonly utilized. Despite its gastrointestinal side effects, most of this group of medicines was safely utilized for decades due to their low cost. They have reverse activities to inflammation, also pharmacological activity of non-steroidal anti-inflammatory medicines, such as antibacterial properties, have been the subject of considerable research in recent years, NSAIDs medicines works in manner that inhibiting all enzymes of cyclooxygenase group. This mechanism is interested in the possibility that cyclooxygenase two enzyme inhibits microbial development, which is characterized by the appearance of cyclooxygenase two enzyme. NSAIDs having derivatives molecules, they were always explored.