Introduction, health is a healthy condition, physically, mentally, spiritually or socially that allows everyone to live productively socially and cheaply as an investment for the development of socially productive and inexpensive human energy sources. Methods, the research used is quantitative research with observational analytic research type with Cross Sectional Study design is a research design that focuses on the dynamics of correlation and associations between independent variables (training, management support, internal interactive communication, management of Human Energy Sources, and the development of service culture) with the dependent variable (job satisfaction) when it coincides. Results, if training is an aspect of Human Resources development that greatly affects the job satisfaction of nurses with an Exp (B) value or an odds ratio of 1.790, meaning that nurses with fairly categorized training tend to be 1, 790 times more satisfied than nurses with training categorized less and because the value of B is positive until training has a positive effect on job satisfaction. Conclusion, if there were influences between aspects of training, management support, internal interactive communication, management of maintenance of human resources, improving the culture of service to nurse job satisfaction. Enhanced and maintain job satisfaction of health workers in this matter nurses. Need maximum training for nurses to improve nursing performance.