Different models were developed to investigate the seismic effect on high-rise structures, and then various techniques/alternatives were examined in order to reduce seismic pressures and, ultimately, to reduce the cost of building construction. We evaluated multiple models of the same architecture with alternative structural systems and infill materials to determine the best strategy to economize the building. For this, we created ETABS models of G+10, G+20, and G+30 story buildings with varying seismic configurations. By analyzing the base shear of RC buildings in the ETAB model, we investigated the influence of AAC infill masonry and brick infill masonry on seismic behavior.