Oral administration remains the most popular because of its many advantages such as simplicity, convenience, convenience, adaptability, and ability to be administered in both solid dosage forms (powder, pill, capsule, and tablet form). Squamous epithelium that is stratified makes up the oral mucosa's outermost layer. Lamina propria, the underlayer, and submucosa constitute the basement membrane. off the basal cell layer, the epithelium's mitotically active layer, to the superficial layer, where cells shed off the epithelium's surface, there are a number of unique intermediate layers. The stratified squamous epithelium that covers the remaining area of the body looks similar to this. Drugs may be directly absorbed and may without first-pass hepatic metabolism, access the systemic circulation due to high vascularization of the buccal or buccal mucosa. To treat NDDS, it is necessary to fabricate oral films containing molecules with an increase in oral bioavailability due to the first-pass effect. The third system class, sometimes referred to as oral wafers in the pertinent literature, is a well-known category of systems that has recently attracted renewed interest in the field of quickly dissolving drug administration. Dispensable oral thin films (OTF) or oral strips (OS), originally sold as breath strips in the confectionery and oral care industries, have developed into an advanced and well-liked delivery system for vitamins and personal care products.