A collection of clinical measurements and the analysis of radiographic images are the primary components that are utilized in the process of diagnosing peri-implantar and periodontal conditions. On the other hand, these clinical situations are not sufficient on their own to determine, much less forecast, periimplant bone loss or potential implant failure. Through the evaluation of biomarkers, it may be feasible to make an early diagnosis of periimplant illnesses and determine the rate at which they progress. In the event that they are discovered, biomarkers of peri-implant and periodontal tissue degradation have the potential to notify doctors prior to the manifestation of clinical symptoms. Because of this, it is essential to take into consideration the possibility of producing chair-side diagnostic tests that are specific for a certain biomarker and indicate the current activity of the illness condition. For metal-free ceramic prostheses, the inflammatory response is reduced regardless of the manner of fabrication; nevertheless, the utilization of computer-aided design and computer-aided manufacturing (CAD/CAM) systems is advised for their construction. Additionally, it is hypothesized that metal-ceramic prostheses produce alterations in the composition of the subgingival microbiota, resulting in a biofilm that is more dysbiotic and contains a larger prevalence of periodontopathogenic bacteria. This may further contribute to the deterioration of periodontal health.