The goal of this review is to look into the challenges of drug permeability over the nail plate and how to improve antifungal drug bioavailability. Because of its limited effects and increased adherence, transungual treatment is considered particularly desirable for the treatment of nail problems. As a result, there are less unfavourable systemic effects. Despite this, topical application's efficacy is limited due to reduced medication penetration across the nail plate. Topical application is limited to mild diseases such as onychatrophia, onychomycosis, leuconychia, and onychogrypos because nail permeability is low. Onychomycosis, a disorder that mostly affects the nails, is best treated with a combination of systemic and topical medication. As a result, drug entry into the nail entity, toward the nail plate, is very desirable for treating nail problems. Drug molecules should be small and nonionic in order to get the best transungual penetration and drug uptake. The internal structure of a human nail, diseases associated with the nail plate, changing the nail plate barriers using chemical methods, permeation enhancers, and physical and mechanical processes used to increase the topical bioavailability of drugs are all covered in existing reviews on nail permeation. To improve transungual penetration, complicated procedures such as photodynamic treatment, Iontophoresis, and ultra sound have been used. This review includes a brief discussion of nail problems, alternative procedures, and transungual medication administration evaluation. The limitations of transungual drug permeability investigations, along with current topical therapies, are also reviewed