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ISSN 2063-5346
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An Organic Acid- 5-Sulfosalicylic Acid : a Metal Free Catalyst for Synthesis of Dihydropyrimidin-2(1H)-ones under No Solvent Condition

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Kabeer Shaikh , Yogesh Salve
» doi: 10.31838/ecb/2023.12.s1-B.257

Abstract

We have been developed an highly functionalized protocol for multicomponent synthesis of Dihydropyrimidin-2(1H)-ones via Biginelli reaction using aromatic aldehyde, ethyl acetoacetate and urea heating at 90oC. The reaction is worked out under solvent free condition and catalyzed by organo-catalyst 5-sulfosalicylic acid. The protocol exhibit several key features like use of non-hazardous, low cost, recyclable and metal free catalyst in addition to shorter reaction time, high yield, simple and clean work-up procedure. The product were confirmed by instrumental analysis

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