Volume - 13 | Issue-1
Volume - 13 | Issue-1
Volume - 13 | Issue-1
Volume - 13 | Issue-1
Volume - 13 | Issue-1
We have been developed an highly functionalized protocol for multicomponent synthesis of Dihydropyrimidin-2(1H)-ones via Biginelli reaction using aromatic aldehyde, ethyl acetoacetate and urea heating at 90oC. The reaction is worked out under solvent free condition and catalyzed by organo-catalyst 5-sulfosalicylic acid. The protocol exhibit several key features like use of non-hazardous, low cost, recyclable and metal free catalyst in addition to shorter reaction time, high yield, simple and clean work-up procedure. The product were confirmed by instrumental analysis