Background:The most widely used resin for denture bases is heat-cure acrylic (HCA). The curing cycle (CC) utilised has an impact on the material's physical and mechanical properties. Identification of an ideal CC is required to achieve maximum monomer-to-polymer conversion and chain branching/cross-linking. Objective: To evaluate and compare the effects of different CC on residual monomer content, porosity and flexural strength of denture base resins. Methods:Two-hundred standard-sized HCA samples were processed using 4 different CC (50 samples per CC) - Group I (9 hours at 74°0C); Group II (2 hours at 74°0C and 1 hour at 100°0C); Group III (1 hour at 74°0C and 30 minutes at 100°0C); and Group IV (30 minutes at 74°0C and 15 minutes at 100°0C).Following that, samples were tested for their residual monomer content, porosity and flexural strength using UV spectrophotometer, stereomicroscope and universal testing machine, respectively.