Ethnobotany is a scientific discipline that examine how people in a particular community interact with the plants in their environment. This study focuses on the ethnomedicinal plants of Churu district of Rajasthan. I found 56 Ethnomedicinal plants from 26 different families which are used to cure many different diseases. The information or data was collected with the help of local tribal peoples, traditional medicinal practitioner, traditional healers, vaids, Hakims and elderly peoples. Various data collection methods were applied to acquire information from the people using a standard questionnaire. Department of Botany, university of Rajasthan Jaipur, India. Largest family found during the study is Fabaceae. The vegetation in Churu district is of xerophytic type and grow in adverse condition of temperature, scanty rainfall, high wind velocity. This area has vast diversity of medicinal plants which need to be conserve by in-situ conservation by establishing botanical garden, germplasm banks in this area. Degradation of forest should be immediately stopped to preserve this vast knowledge of ethnobotany. Indian government should enact strict rules and make stringent laws to preserve these Ethnomedicinal plants wealth.