The present investigation deals with the nature the binary metal ligand complexes formed in between essential metal ions with Histamine in (0.0-2.5% v/v) TX100-water mixture. pH meter is employed for this investigation, and the data is obtained by maintaining the temperature at 303.0 K and ionic strength of the medium at 0.16 mol L-1.There are number of metal ligand complexes formed and which were studied by a computer modelling known as MINIQUAD75. The titremetric data is subjected to statistical analysis and the selection of best fit chemical model is done using the statistical parameters such as R-factor, Standard deviation and U-Correction etc. In this investigation, it observed that electrostatic and non-electrostatic forces are showing noticeable effect on the stability constants of binary metal ligand complexes formed with respective to the mole fraction of the TX-100. Percentages of species and species distribution diagrams are presented.