Context: This paper aims to explain and develop a high-performance liquid chromatography (HPLC) technique to measure Alprazolam Benzoate (APB) in pharmaceuticals. Method: The form of (APB) was ascertained using the Reversed-Phase HPLC (RP-HPLC) technique, the findings of which were obtained. An Ion Pac column and HPLC-UV system with an Arcus EP-C18 sizing 5 m, 250 mm, and 4.6 mm were used to conduct the chromatographic analysis. Acetonitrile was used as the mobile phase with a 0.5 M potassium dihydrogen orthophosphate + Triethylamine 30:70 (v/v) buffering at pH 4.5 and an average flow rate of 1.0 ml/min. UV detection was performed by the HPLC equipment at 310 nm.