To analyze adverse drug reactions and their Pharmacoeconomic impact. To increase a listing of signs for figuring out destructive drug activities in hospitalized patients. To compare the frequency, severity and preventability of destructive drug reactions stated from a medication department. To Development and compare predictors for the value control of destructive drug reactions. To Development and validation of a Predictor version for severity of destructive drug reactions in hospitalized patients. An ambispective observational have a look at become carried out in a tertiary care Teaching sanatorium of Medicine department. The information become labeled primarily based totally on numerous parameters like age, gender, co morbidities, medication utilization in Patients admitted with destructive drug reactions and sufferers recognized with destructive drug reactions after admission within side the sanatorium and their monetary burden at the sufferers have been amassed and analyzed. The occurrence of ADRs documented on this examine turned into better than the ones research mentioned from comparable examine set up. Many of the mentioned research used spontaneous reporting technique which turned into normally related to decrease charges of reporting. Use of extensive tracking technique primarily based totally on energetic surveillance of statistics is probably useful in higher detection and documentation of ADRs. This version will assist to expect the severity of a response for the duration of preliminary levels of growing ADR, thereby probably supporting in identifying control approach for a selected patient