Background: Graft-versus-Host Disease (GVHD) is a condition that may occur after an allogeneic transplant. In GVHD, the donated bone marrow or peripheral blood cells view the recipient’s body as foreign and the donated cells/bone marrow attack the body. Materials and Methods: It is an ambispective study conducted in a tertiary care hospital. All children diagnosed as acute graft versus host disease post-transplant were included in the study. Results: Acute GVHD was seen in 35 patients (23.48%) who underwent BMT during the study period. Of these 35, fourteen (40%) children who developed aGVHD had undergone matched related BMT while 21(60%) had undergone partially matched related BMT. Mortality as a result of aGVHD was seen in 9 (25.7%) patients. Of these 3(33.33%) deaths due to aGVHD were in matched related donor group while 6 (66.67%) were in the partially matched related donor group. Conclusion: Although significant improvements have been made, early transplant-related mortality and GVHD remain major obstacles to safe transplantation.