With a populace of over 1.2 billion people, it is anticipated that our country is domestic to over fifty percent of the arena’s SCD (Sickle Cell Disease) sufferers (Kate et. al., 2002). Likewise, it is seen that sickle cell is widespread in lots of tribal groups, the very best prevalence seems to be in 3 specific socioeconomically deprived communities, recognized as the Scheduled Castes (SC), Scheduled Tribes (ST), and other Backward classes (OBC) (Kate et. al., 2002). Each of those categories includes numerous distinct big ethnic groups, which have practiced marrying within a selected group, for millennia, and for this reason constitutes genetic isolates. Therefore, it is likely to be beneficial for the functions of making plans for genetic counselling services, manage packages, medical provider provision or genetic epidemiological studies, screening ought to generate prevalence estimates of the βs gene in every ethnic group. Therefore, the superiority of the βs gene has been well described within the ST populace (Italia et. al., 2009).