Deep vein thrombosis (DVT) is a part of condition called venous thromboembolism. DVT occurs when a blood clot (thrombus) forms in one or more of the deep veins in the body, usually in the legs. DVT can cause leg pain or swelling, but may occur without any symptoms. DVT is a serious condition because blood clots in the veins can break loose, travel through the blood stream; obstruct the lungs and blocking the blood flow. So stop clot intervention package is very much important to prevent the DVT. Methods: A quasi experimental one group pre- test and post-test design adopted in this study. Probability stratified random sampling technique used in this study to select 35 care givers of high risk patients to develop deep vein thrombosis at SNHRC, Vellore. The self-structured knowledge questionnaire and practice check lists were prepared to assess the knowledge and practice of the care givers. Descriptive and inferential statistics were used for analysis and interpretation of data. Result and Interpretation Findings of this study shows in pre intervention levels of the knowledge, out of 35 samples, 94.29 percent were inadequate, 5.71 percent were moderate adequate and none of them were in adequate levels of knowledge. Whereas in post intervention none of them were in inadequate, 42.86percentwere moderate adequate & 57.14percent were adequate levels of knowledge. In pre and post intervention levels of practices, out of 35 samples, 60percent were poor competency, 40percent were fair competency and none of them were in good competency levels of practices. Whereas in post intervention in day- 1, none of them was poor competency, 2.86percent were fair competency and 97.14percent were good competency. In day-2 and day 3, none of them was poor & fair competency and 100percent were good competency levels of practices. In the knowledge pre intervention mean score was 8.50 & SD 2.92, whereas in post intervention means score was 20 and SD 1.93, mean difference 11.5 and paired ‘t’ value was 21.62 (TV= 3.79) was significant at p< 0.001 level. Hypothesis was tested and accepted. In the practice pre intervention, mean score was 8.2 and SD 1; whereas in post intervention, day -1 mean score was 19.9, SD1.2, mean difference 12 & paired t value 4.95 (TV=3.75); day- 2 mean score was 20.14 & SD 1, mean difference 11.91 &paired t value 38.57 (TV=3.55); in day - 3 mean score was 20.4 & SD 1.2, mean difference 12.2 & paired ‘t’ value 34.2l (TV=3.65). That was more significant at p<0.001 level. There are improvements in the knowledge and practices of the care givers of high risk patients to develop DVT. Hypothesis one was tested and accepted. The comparison of post intervention practices between day1 & day2 and between day2 & day3. In that between day 1 & day 2 mean differences 1.8, SD 0.56, paired t value 6.20 & table value 5.96. That was more significant at p<0.001 level. In between day 2 & day 3, mean difference 0.8, SD 0.04, t value 6.20 & table value 4.03. That was more significant at p< 0.01 level. In the ‘Chi-square’ values of selected demographic variables and post intervention score on levels of knowledge of the care givers of high risk patients to develop DVT. The ‘Chi-square’ values of selected demographic variables such as sex and previous knowledge regarding DVT were significant and age, educational status, occupation, income of the care giver & sources of information were nonsignificant. Hypothesis two was tested and accepted. In association between the post interventions levels of practices with selected demographic variables were non- significant. Hence an H2was rejected.