Based on a computational social science research paradigm, this research used a mixed-method design of a qualitative research plus a quantitative research, and this research put forward the hypothesis of the correlation between entrepreneurial spirit, business ethical decision-making and ethical awareness, and constructed a theoretical model of 500 entrepreneurs from Top 500 Chinese Private Enterprises (2021) as the sample. Secondary data such as video, audio and text of speeches, interviews delivered in public by sampled entrepreneurs between January 1, 2019 and December 31, 2021 were used as the data source to test the theory with computer-aided text analysis (CATA) method with natural language processing (NLP), binary logistic regression, parallel mediation test and likelihood chi-square ratio test. From the conclusion, it can be seen that entrepreneurial spirit has differential influence on business ethical decisionmaking under different decision-making mechanisms, and entrepreneurial spirit can improve business ethical decision-making. At the same time, ethical awareness plays a masking effect in the process of influencing entrepreneurial spirit on business ethical decision-making, which provides methodological references for explaining the current social phenomena and ethical decision-making in business management.