Chronic rhinosinusitis is inflammation of the mucosa of nose and paranasal sinuses which lasts for more than 12 weeks and may lead to polyp formation. Endoscopic sinus surgery is the most effective management for Sino-nasal polyposis. Vitamin D is found to have properties of inhibiting angiogenesis, inhibiting cellular proliferation and anti-inflammatory role. Objective: To assess the role of Vitamin D in minimising intraoperative bleeding and prevent postoperative recurrence in patients undergoing surgical management for Nasal polyposis. Materials and Methods: A randomized prospective study was conducted in the Department of otorhinolaryngology, in tertiary health centre, Tamil Nadu, India from June 2020 to October 2021. Sixty consecutive patients were enrolled in two categories, A (n=30) & B (n=30). All the patients underwent detailed history, clinical examination, nasal endoscopy and Computed tomography of nose and paranasal sinuses. Group A in addition to routine medications, also received oral Vitamin D 1000 IU per day for 2 weeks preoperatively and 6 weeks postoperatively. Patients were followed up at 1 month, 3 months and 6 months. Results: Most of the patients fell under the age group of 30-40 years. No difference was noted between the groups based on symptomatology. The mean intraoperative blood loss in Group A (345.33 ±42.24) and group B (347.33 ±36.95) with no significant mean difference. There is significant mean difference between Group A and Group B when compared with SNOT 22 score and Meltzer Endoscopic staging at 6 months post-operative. 4 out of 30 patients belonging to Group B reported recurrence of nasal polyposis when compared to Group A with no recurrence. No adverse effects were observed. Conclusion: This study shows the efficacy and safety of Vitamin D supplementation in reducing the recurrence rate significantly, but its role in controlling intraoperative bleeding is minimal.