The COVID-19 pandemic has significantly impacted the healthcare industry, including multispecialty hospitals in Tamil Nadu, India. This paper examines the impact of the pandemic on human resource management (HRM) practices in these hospitals. The study is based on a comprehensive review of the literature and primary data collected through surveys and interviews with Professionals and HR personnel in multispecialty hospitals in Tamil Nadu. The study found that HRM practices in multispeciality hospitals in Tamil Nadu have been significantly impacted by the COVID-19 pandemic. The COVID-19 pandemic has placed hospital employees at the forefront of the battle against the virus, exposing them to a multitude of perceived threats. This abstract explores the perceived threats faced by hospital employees during the pandemic. The primary threats identified include an increased risk of exposure to the virus, a shortage of personal protective equipment (PPE), uncertainties surrounding the novel virus, and the subsequent emotional and mental health impact. Hospital employees have faced elevated levels of stress, anxiety, and burnout as they navigated through the challenges of working in a high-risk environment with limited knowledge about the virus. Additionally, social stigma and discrimination towards healthcare workers have exacerbated the perceived threats. Inadequate support and resources, such as staffing shortages and limited healthcare infrastructure, have further contributed to the perceived threats experienced by hospital employees. Understanding these perceived threats is essential for healthcare systems and policy makers to effectively address the needs of hospital employees, provide them with the necessary support and resources, and ensure the well-being of these vital frontline workers.