The present review aims to explore the pharmacological activities of Plumeria alba Linn. The medicinal value of Plumeria species in the treatment of various human ailments is mentioned in Ayurveda, Charaka Samhita, and Sushrita Samhita. Plumeria alba Linn. is widely used in perfumery and traditional medicinal systems for various diseases. Plants have a variety of compounds like glycosides, alkaloids, terpenoids, and steroids which possess important diverse pharmacological activities to alleviate various diseases and disorders. Extracts of various parts of this plant can be safely used as antifungal, antioxidant, antiacne, hypolipidemic, antiulcerogenic, antibacterial, cytotoxic, anti-inflammatory, hepatoprotective, etc activities. The present literature review has been envisaged to provide scientific information about the pharmacological profile. Plumeria alba has been scientifically validated by various researchers all over the world. In the Indian system of medicine plants are a vital source of drugs from the ancient time. This alternative system of medicine is gaining increasing popularity worldwide. This paper enumerates the pharmacological importance of P. alba which may help the researchers to set their minds for approaching the usefulness, efficacy, and potency of the plant.