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ISSN 2063-5346
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A STUDY OF MEAN PLATELET VOLUME IN TYPE 2 DIABETES MELLITUS PATIENTS WITH AND WITHOUT VASCULAR COMPLICATIONS : A COMPARATIVE STUDY

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Dr. Nishit Mashru, Dr. Shilpa Patil
» doi: 10.31838/ecb/2023.12.s2.023

Abstract

Background: Diabetes has many vascular complications including Coronary Artery Disease, Acute Ischemic Cerebrovascular Accident and Diabetic Retinopathy. Many platelet parameters can detect these vascular complications by analyzing the prothrombotic stage of platelets. To evaluate this we studied the Mean Platelet Volume in patients with Type 2 Diabetes Mellitus with the vascular complications and without the vascular complications. Methods: This was a single centre hospital-based prospective study conducted in patients admitted to the Krishna hospital under medicine wards and ICU over a period of 18 months from January 2021 to June 2022. We divided the study participants in two groups, type 2 diabetes patients with complications (Group A) and without complications (Group B). We studied various parameters in these groups and correlated them with MVP. Results: Most common age group was 61 to 70 years in both the groups. Group A patients had 31 males (51.67%) and in Group B patients there were 38 males (63.33%). Significant difference was seen in the duration of diabetes of the two groups. (p<0.001). Group A patients had mean HbA1c levels of 8.12 (± 2.36) while in Group B patients the mean HbA1c levels of 6.92 (± 1.45). The HbA1c was statistically significantly raised in patients with Type 2 Diabetes mellitus with vascular complications (p<0.001). There was weak positive correlation of Mean Platelet Volume with HbA1c, Fasting Blood Sugar, Post Prandial Blood Sugar, (0.303, 0.390, 0.314) respectively in Group A as compared to very weak positive correlation of Mean Platelet Volume with HbA1c, Fasting Blood Sugar, Post Prandial Blood Sugar, (0.007, 0.018, 0.072) respectively in Group B. Conclusion: In present study we observed that in diabetes mellitus patients with vascular complications had significantly raised Mean Platelet Volume (MPV) and Platelet Distribution Width (PDW). We conclude that the MPV can be utilized as a screening tool to look for diabetes cases that may have vascular problems.

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