The emergence of Nanotechnology in the field of medicine has led to new horizons since 1990s, which also widely used in pharmaceutical industry, chemical industry, bio-sciences, textiles industry etc. Viral infections are severely effecting global population and causing hazards to life. SARS-CoV-2 has badly affected human beings worldwide and also including economic distress. Silver nanoparticles having potential antiviral, antibacterial and antifungal property through different mode of actions. Virus replicates by using host cells, therefore it is so challenging to develop safe and effective antiviral agents. However, targeting virus without harm to host cell is very difficult to design such a safer and effective drug. The research is continuing for the evaluation of antiviral property of silver nanoparticles and several studies had scientifically claimed the potential antiviral property of silver nanoparticles against different species of virus and viron. In this review, we discuss the antiviral property of silver nanoparticles, mechanism of action, method of synthesis, their characterization methods, safer dose and toxicity, application in different fields.