The research focuses on the pivotal role of healthcare workers' performance in the government healthcare sector of Saudi Arabia. It emphasizes the importance of organizational agility in responding to dynamic healthcare landscapes and improving workforce effectiveness. Research Hypotheses The study posits that organizational agility significantly impacts the performance efficiency of healthcare personnel in the government healthcare sector in Saudi Arabia. Sub-hypotheses explore the impact of compatibility, prioritization, and roles/responsibilities on performance efficiency. Challenges Facing Healthcare Workers Challenges include limited resources, workload issues, administrative burdens, training gaps, regulatory compliance, and cultural factors. Importance of Performance Efficiency Performance efficiency optimizes resource utilization, improves patient outcomes and satisfaction, reduces costs, enhances accessibility, meets national healthcare goals, and maintains competitiveness. Impact of Organizational Flexibility on Healthcare Workers Organizational flexibility promotes work-life balance, adaptability, collaboration, professional development, autonomy, retention, and innovation among healthcare workers. Methodology The research employs a descriptive analytical method, sampling 270 healthcare personnel from the government healthcare sector in Saudi Arabia using a questionnaire with Likert scale statements. In conclusion, the study underscores the critical link between organizational agility and performance efficiency among healthcare personnel in Saudi Arabia's government healthcare sector, offering insights into improving workforce effectiveness amidst dynamic healthcare landscapes.