The study aimed to explore the relationship between job burnout and job satisfaction among nurses in the government health sector in the Kingdom of Saudi Arabia. It utilized a descriptive survey method to achieve the study's objectives, encompassing all nurses in the Saudi government health sector as its population. The study sample consisted of 820 nurses from the Saudi government health sector, selected randomly. To accomplish the study's objectives and gather all relevant data, the study employed the job burnout scale and the job satisfaction scale. In light of this, the study found a statistically significant inverse (negative) relationship between overall job burnout and job satisfaction. The results indicated that as job burnout levels among nurses in the Saudi government health sector increase, their levels of job satisfaction decrease. Based on the findings, the study recommends the necessity of 1. Develop and implement stress management and reduction programs tailored specifically for nurses. These programs should include techniques such as mindfulness, meditation, and time management skills to help nurses cope with the high levels of stress associated with their job. Encourage policies that promote a healthy work-life balance. This could include more flexible scheduling options, the availability of part-time positions, and ensuring adequate days off and vacation time.