The study aimed to explore the nature of the relationship between psychological burnout and job satisfaction among healthcare staff in the government health sector in Riyadh, as well as to identify the levels of psychological burnout and job satisfaction among healthcare staff working in the government health sector in Riyadh. The researchers used the descriptive analytical method to achieve the study objectives, and the study population consisted of all healthcare staff in the government health sector in Riyadh. The study sample consisted of (205) healthcare staff in the government health sector in Riyadh, selected randomly. The researchers used two instruments to achieve the study objectives and collected all its data: the Psychological Burnout Scale and the Job Satisfaction Scale. In light of the results, the study concluded several findings, the most important of which was the presence of a statistically significant inverse (negative) relationship between the total score of psychological burnout and the total score of job satisfaction. The results indicate that as the levels of psychological burnout among healthcare staff in the government health sector in Riyadh increase, their levels of job satisfaction decrease. Based on the results, the study recommends There is a need to develop training programs aimed at enhancing resilience skills and managing psychological stress for healthcare personnel. This will enable them to effectively cope with job demands and maintain their psychological well-being. It is essential to provide psychological and social support programs for employees in the governmental healthcare sector in Riyadh, whether through psychological consultations or community social support, to offer necessary support in facing psychological challenges they may encounter.