Benzothiazoles have a significant impact on biochemistry and medicinal chemistry because of their great biologic and pharmacological activity. Undoubtedly, one of the biggest issues facing scientists today is the creation of chemical synthesis. With the reaction of 2-aminobenzenethiol by that of acids, ketones, aldehydes, cyclization and acyl chlorides of carbon dioxide and thioamide as raw materials, researchers presented significant advancements in the biosynthetic pathways of benzothiazole substances associated with green chemical reactions in this research article. In this review researchers predicted the biosynthetic pathways of benzothiazoles