Aromatic heterocycles especially indole plays an important part in treatment of cancer. This review highlights compounds in development bearing indole moiety in their scaffold for the treatment of cancers. This review also highlights the utilization of colchicine binding site in order to inhibit tubulin polymerization. Docking studies shows that colchicine binding site is used by various indole derivatives to exert their action. Vincristine and vinblastine are the natural compounds which have the anticancer activity but they act on the vinca domain of the tubulin protein. Vinca domain can be too large for small ligands, so small molecules can utilize colchicines binding site to inhibit microtubule polymerization.